MOST Verado engines utilized knock sensors. However, NOT all Verado models with Knock Sensors were equipped with multi-fuel "performance" strategies.
That feature originally showed up on the 275 Verado (which was later discontinued). Feature also came in some of the Verado PRO models... however, there were differences even in the Race Lineup (the 350 SCI, predecessor of the 350 Verado, didn't utilize knock sensors and required use of ONLY high-test fuel).
What would apply to engines with higher compression and/or timing strategies is that the fuel octane that MATCHES what the engine was calibrated with will burn most efficiently, with the lowest carbon emissions.
This is one of the reasons that you will hear folks commenting that they see a lot more "prop soot" on their Optimax engine when running fuel that's higher octane than what is required. Many find that reduces considerably just by switching back to the correct fuel.
Imagine how the combustion chamber, spark plugs, exhaust, and depending on engine type- Injectors, might benefit from considerably lower carbon emissions.