I hate to hear this, I wish you luck with your job search!
As for my advice, here are a few things to consider;
1. File for Unemployment right away.
2. Check to see if you're able to get benefits through your wife's employer. If you can't, sign up for Cobra right away.
3. Review and update your resume as needed. If you don't have one, find someone to help you make a good one, it really does make a difference.
4. Regarding your job search; setup a LinkedIn account and be sure to add your resume information to your profile, it will help you find the right type of open position in your area very quickly.
5. Sign up with several job posting sites such as Indeed.com and Zip Recruiter. Again, enter your resume information so you can easily apply for open positions.
6. Keep a spreadsheet of every job you apply for and keep the contact name and email address of every person you hear back from or have an interview with... send "follow up" and "thank you" emails every time.
7. Lastly, stay positive and don't panic, you'll be okay.
Once you are working again, try to make yourself more prepared for this type of an event, no matter what that might mean to you personally. (some may need a larger emergency savings account, some need to develop a "plan B", some people need to continually network and make new business contacts as you never know where your next job will come from), every person needs something different to be more prepared.
Good luck!